Gastroduodenal mucosal alkaline secretion and mucosal protection.
نویسندگان
چکیده
The gastroduodenal mucosa is a dynamic barrier restricting entry of gastric acid and other potentially hostile luminal contents. Mucosal HCO3(-) is a key element in preventing epithelial damage, and knowledge about HCO3(-) transport processes, including the role of the cystic fibrosis transmembrane conductance regulator channel, and their neurohumoral control are in rapid progress.
منابع مشابه
Invited Review Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin
Allen, Adrian, and Gunnar Flemström. Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin. Am J Physiol Cell Physiol 288: C1–C19, 2005; doi:10.1152/ajpcell.00102.2004.—Secretion of bicarbonate into the adherent layer of mucus gel creates a pH gradient with a near-neutral pH at the epithelial surfaces in stomach and duodenum, providing the first line of mucosal protection...
متن کاملGastroduodenal mucus bicarbonate barrier: protection against acid and pepsin.
Secretion of bicarbonate into the adherent layer of mucus gel creates a pH gradient with a near-neutral pH at the epithelial surfaces in stomach and duodenum, providing the first line of mucosal protection against luminal acid. The continuous adherent mucus layer is also a barrier to luminal pepsin, thereby protecting the underlying mucosa from proteolytic digestion. In this article we review t...
متن کاملAcid stimulated alkaline secretion in the rabbit duodenum is passive and correlates with mucosal damage.
Low luminal acid concentrations stimulate alkaline secretion (AS) by the duodenal mucosa. We investigated acid stimulated alkaline secretion by proximal rabbit duodenal mucosa in an Ussing-chamber under different luminal acid concentrations and its relation to mucosal damage. Luminal alkalinisation and potential difference (PD) were measured and mucosal damage was investigated histologically. L...
متن کاملAegle Marmelos Enhances Gastric Mucosal Protection: Relevance for NSAIDS-Induced Gastric Mucosal Injury
Objective: In order to study the gastroprotective effect of Aegle marmelos extract (AM), this study was undertaken on aspirin-induced ulcerogenesis in cannulated free-moving rats. Background: Most of the non-steroidal anti-inflammatory drugs (NSAIDs) including aspirin (ASP) cause gastric ulcer. The efficacy of several plants for the treatment of gastroduodenal disease is confirmed by clinical r...
متن کاملInvestigation of Gastroduodenal Mucosal Injury in Japanese Asymptomatic Antiplatelet Drug Users
Antiplatelet drugs are widely used for the prevention of cardiovascular disease and cerebral vascular disorders. Although there have been several studies on gastroduodenal mucosal injury with gastrointestinal (GI) symptoms such as GI bleeding, in antiplatelet drug users (including low-dose aspirin (LDA)), there have been few reports on the association between antiplatelet drug use and gastroduo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society
دوره 16 شماره
صفحات -
تاریخ انتشار 2001